Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products
نویسندگان
چکیده
منابع مشابه
Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products
Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic indications and have revolutionized the field of aesthetic medicine so that they are the leading cosmetic procedure performed worldwide. Studies show that onabotulinumtoxinA, abobotulinumtoxinA, and incobotulinumtoxinA are comparable in terms of clinical efficacy. Differences between the products relate to th...
متن کاملResponse to Commentary by W. Jost on: Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products
Differences in manufacturing processes can affect the properties of biological products. This is especially true for products based on botulinum toxin. The manufacturing process for Xeomin /Bocouture (NT 201, incobotulinumtoxinA, INCO) employs chromatographic methods and produces a pure neurotoxin without any other bacterial contaminants such as the so-called complexing proteins or clostridial ...
متن کاملThe potency testing of botulinum neurotoxin products.
I should like to strongly endorse the article by Andy Pickett,1 published in the September issue of ATLA, in which he criticises the lack of published information relating to a new in vitro method developed by Allergan Inc., which has received regulatory approval as a replacement for the LD50 mouse bioassay for the potency testing of a botulinum neurotoxin (BoNT) series of products. Clearly, th...
متن کاملCharacterization of SNARE Cleavage Products Generated by Formulated Botulinum Neurotoxin Type-A Drug Products
The study evaluated substrate cleavage product(s) generated by three botulinum neurotoxin serotype A (BoNT/A) medicinal drug products utilizing a novel and highly specific, light-chain activity, high-performance liquid chromatography (LCA-HPLC) method. Samples were reacted with a commercially available BoNT/A fluorescent substrate derived from the SNAP-25 sequence. Reaction products were separa...
متن کاملNeurologic uses of botulinum neurotoxin type A
This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical tr...
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ژورنال
عنوان ژورنال: Drugs in R&D
سال: 2015
ISSN: 1174-5886,1179-6901
DOI: 10.1007/s40268-014-0077-1